The condition involves the death of small areas of brain tissue around fluid-filled areas called ventricles. The damage creates "holes" in the brain. Causes PVL is much more common in premature infants than in full-term infants. A major cause is thought to be changes in blood flow to the area around the ventricles of the brain. This area is fragile and prone to injury, especially before 32 weeks of gestation. Infection around the time of delivery may also play a role in causing PVL.
|Published (Last):||11 January 2010|
|PDF File Size:||3.61 Mb|
|ePub File Size:||2.6 Mb|
|Price:||Free* [*Free Regsitration Required]|
The condition involves the death of small areas of brain tissue around fluid-filled areas called ventricles. The damage creates "holes" in the brain.
Causes PVL is much more common in premature infants than in full-term infants. A major cause is thought to be changes in blood flow to the area around the ventricles of the brain. This area is fragile and prone to injury, especially before 32 weeks of gestation. Infection around the time of delivery may also play a role in causing PVL. The risk for PVL is higher for babies who are more premature and more unstable at birth. Premature babies who have intraventricular hemorrhage IVH are also at increased risk for developing this condition.
Treatment There is no treatment for PVL. This helps reduce the risk of developing PVL. Outlook Prognosis PVL often leads to nervous system and developmental problems in growing babies. It may cause cerebral palsy CP , especially tightness or increased muscle tone spasticity in the legs. Babies with PVL are at risk for major nervous system problems. These are likely to include movements such as sitting, crawling, walking, and moving the arms.
These babies may need physical therapy. Extremely premature babies may have more problems with learning than with movement. A baby who is diagnosed with PVL should be monitored by a developmental pediatrician or a pediatric neurologist. The child should see the regular pediatrician for scheduled exams. Alternative Names.
When a person suffers a periventricular leukomalacia injury, these functions are impaired. PVL is a strikingly common causal factor among children with Cerebral Palsy that leads to intellectual impairment and spasticity that require therapy and treatment. What is Periventricular Leukomalacia? Brain injury — Damage to the white matter brain tissue Periventricular leukomalacia, or PVL, is a type of brain damage that involves the periventricular white matter of the brain.
Periventricular Leukomalacia, or PVL
These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional. Where to Start MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic. In-Depth Information Medscape Reference provides information on this topic.
Pathology It likely occurs as a result of hypoxic-ischemic lesions resulting from impaired perfusion at the watershed areas, which in premature infants are located in a periventricular location. It is likely that infection or vasculitis also play a role in pathogenesis. Radiographic features Ultrasound Cranial ultrasound provides a convenient, non-invasive, relatively low-cost screening examination of the haemodynamically-unstable neonate at the bedside. The examination also imparts no radiation exposure. Sonography is sensitive for the detection of hemorrhage, periventricular leukomalacia, and hydrocephalus. On ultrasound, hyperechoic areas are firstly identified in a distinctive fashion in the periventricular area, more often at the peritrigonal area and in an area anterior and lateral to the frontal horns periventricular white matter should be less echogenic than the choroid plexus. These are watershed areas that are sensitive to ischemic injury.