GASTROPATHY NSAID PDF

Congestion of superficial capillaries in the lamina propria in the absence of significant inflammation [5] Low mag. Immunohistochemistry[ edit ] Mucin expression is reported to be altered in reactive gastropathy in comparison with normal gastric mucosa as well as H pylori gastritis. Aberrant expression of the secreted mucins was also demonstrated. These alterations in mucin expression were shown in cases of both nonsteroidal anti-inflammatory drug NSAID -associated and bile reflux—associated reactive gastropathy. Additionally, these changes are dissimilar to those seen in H pylori gastritis, reflecting the differences between these gastropathies. Reactive gastropathy is also characterized by differences in cytoskeletal structure and cell cycle kinetics, as compared with normal gastric mucosa and H pylori gastritis.

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Congestion of superficial capillaries in the lamina propria in the absence of significant inflammation [5] Low mag. Immunohistochemistry[ edit ] Mucin expression is reported to be altered in reactive gastropathy in comparison with normal gastric mucosa as well as H pylori gastritis.

Aberrant expression of the secreted mucins was also demonstrated. These alterations in mucin expression were shown in cases of both nonsteroidal anti-inflammatory drug NSAID -associated and bile reflux—associated reactive gastropathy.

Additionally, these changes are dissimilar to those seen in H pylori gastritis, reflecting the differences between these gastropathies. Reactive gastropathy is also characterized by differences in cytoskeletal structure and cell cycle kinetics, as compared with normal gastric mucosa and H pylori gastritis.

The localization of CK7 and CK20 staining was modified, with extension toward the deep foveolar region. In contrast to H pylori gastritis, the surface epithelium lacked Ki67 expression and a downward elongation of the proliferative zone was noted. As a reactive gastropathy may mimic a true gastritis symptomatically and visually in an endoscopic examination , it may incorrectly be referred to as a gastritis. Even aware of the underlying etiology of the pathologic process, e.

NSAID use, the label "chemical gastritis" is applied to a chemical gastropathy.

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Current approaches to prevent NSAID-induced gastropathy – COX selectivity and beyond

Received Dec 30; Accepted Feb This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. This article has been cited by other articles in PMC. Their analgesic, anti-inflammatory, and antipyretic actions may be beneficial; however, they are associated with severe side effects including gastrointestinal injury and peptic ulceration.

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Current Perspectives in NSAID-Induced Gastropathy

Gastrointest Endosc Clin N Am. Nonsteroidal anti-inflammatory drug gastropathy. NSAID gastropathy is characterized by subepithelial hemorrhages, erosions, and ulcers. Although gastric lesions are common at endoscopy, clinically significant problems are uncommon. Subepithelial hemorrhages and erosions may cause minor bleeding, but ulcers must be present for major bleeding, gastric outlet obstruction, or perforation to occur. NSAID use is associated with an increased risk of gastrointestinal complications; this risk is increased with older age, a history of peptic ulcer, a history of gastrointestinal bleeding, higher doses of NSAIDs, and concomitant use of corticosteroids. NSAIDs do not cause a diffuse histologic gastritis i.

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