Top Edited by Alex S. Evers, M. Kharasch, M. Pages: 1, A thorough understanding of anesthetic pharmacology is fundamental to clinical practice, and much of the ongoing scientific investigation in anesthesiology is in the field of pharmacology.
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Edited by Alex S. Evers, M. Philadelphia, Churchill Livingstone, Pages: 1, Louis, Missouri , and Mervyn Maze, M. With so many authors, there is less cohesion and more repetition than in a single-authored text; however, the excellent breadth and detail of this book could only be accomplished with the outstanding team of experts assembled by the editors. The textbook has three sections: I. Principles of Drug Action 7 chapters, pages , II. Pharmacologic Basis of Clinical Practice 32 chapters, pages.
The first two sections provide basic principles of pharmacology and physiology, and the third section covers the clinical pharmacology of major drug classes. Section I chapters 1—7 is a concise but thorough review of basic pharmacokinetics and pharmacodynamics and includes current topics such as pharmacoeconomics and pharmacogenomics.
Section II covers physiology at both the cellular and systems levels. Section III presents clinical pharmacology by drug classification e. This organization results in some overlap between the two background sections and the chapters on clinical practice.
The division of part III into chapters based on specific drug uses also results in some repetition for drugs employed in multiple contexts. In other cases, the clinical practice chapter contains even more scientific detail than the basic physiology chapter e. However, these problems do not detract from the overall utility of the book.
There is a uniform feel throughout the book; each chapter follows the same basic outline and is subdivided into sections on Mechanisms of Action, Clinical Pharmacology, Adverse Effects, Practical Aspects of Drug Use, and Dosage and Administration. There are a few notable omissions for a complete textbook of anesthetic pharmacology.
For example, the anesthetic implications of statin therapy for hyperlipidemia and anitiviral therapy for HIV infection and their effects on cytochrome P—mediated drug interactions are not discussed despite the prevalent use of these drugs by patients treated by anesthesiologists. Other topics that receive short shrift include dantrolene and treatment of malignant hyperthermia, properties of commonly used and abused opioids e.
As with many works of this size, the quality of individual chapters is variable, but there are many gems. The editors cannot possibly check every fact or citation, and some errors have crept in. Thus, it is unlikely that bronchospasm after rapacuronium administration is due to histamine release as suggested in chapter 33, but rather is the result of selective muscarinic receptor type 2 blockade; fortunately, such mistakes seem to be rare.
Minor errors are present throughout the text including the title page and citations e. There is also some inconsistency in terminology e.
The immense time and effort required to produce this book is likely the reason for the paucity of references later than It certainly deserves a place in every anesthesia departmental library and is highly recommended for those interested in staying on the leading edge of the specialty. This represents a fine start to what we fully anticipate will become the classic text on pharmacology and physiology as they relate to the practice of anesthesiology.
Anesthetic Pharmacology Physiologic Principles & Clinical Practice
Edited by Alex S. Evers, M. Philadelphia, Churchill Livingstone, Pages: 1, Louis, Missouri , and Mervyn Maze, M.
As pharmacologj many works of this size, the quality of individual chapters is variable, but there are many gems. Ventilation, Oxygenation, Regulation I particularly recommend this book to trainees. Login Log in to access full content You must be logged in to access this feature. Section I chapters 1—7 is a concise but thorough review of basic pharmacokinetics and pharmacodynamics anrsthetic includes current topics such as pharmacoeconomics and pharmacogenomics. The division of part III into chapters based on specific drug uses also results in some repetition for drugs employed in multiple contexts. Pathophysiology and Preventative Pharmacologic Considerations. Book ratings by Goodreads.