Janeway Jr, professor of immunobiology at Yale University School of Medicine in New Haven and one of the pre-eminent modern immunologists, died on 12 April of lymphoma. Most scientists only dream of contributing to a paradigm shift — Janeway personally initiated one. He reasoned that there must be mechanisms to ensure that an immune response is not only specific, but is also appropriate. Now, it is one thing to have a great idea and another to prove it. With Ruslan Medzhitov, a postdoctoral fellow and then colleague at Yale, Janeway showed that mammalian relatives of the Toll protein — a key player in the inflammatory response in fruitflies — constitute one set of pattern-recognition receptors. Indeed, we now know that the Toll-like receptors recognize a wide array of structures associated with various pathogens, including lipopolysaccharide found in the cell wall of many bacteria and double-stranded RNA.

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Children: 3 Charles Alderson Janeway, Jr. Janeway, Janeway was raised in Weston, Mass. By earning his medical degree from Harvard Medical School in , Janeway joined a long family line of prominent physicians. In addition to his father, his grandfather, Theodore C. Janeway , was the first full-time professor of medicine at the Johns Hopkins University School of Medicine , and his great-grandfather, Edward G.

In he was promoted to Professor of Pathology and in he became one of the founding members of the newly created Section of Immunobiology at Yale University School of Medicine. Janeway was one of the leading immunologists of his generation whose ideas formed many of the concepts that are the basis of immunology today.

He made major contributions to our understanding of T lymphocyte biology. He pioneered the modern studies of innate immunity, which is the first line of defense against infections. He proposed a general theory of innate immune recognition pattern recognition theory and suggested the principles of innate control of adaptive immunity. He also published more than scientific papers. Janeway also served on the board of directors of several research institutes, including the Trudeau Institute , and the Federation of American Societies for Experimental Biology.

He was president of the American Association of Immunologists from Janeway was married to H. Kim Bottomly , Ph. Janeway, M. He died on April 12 in his home in New Haven.


Charles Janeway

The humoral immune response is initiated when B cells that bind antigen are signaled by helper T cells or by certain microbial antigens alone Armed helper T cells activate B cells that recognize the same antigen Antigenic peptides bound to self MHC class II molecules trigger armed helper T cells to make membrane-bound and secreted molecules that can activate a B cell Isotype switching requires expression of CD40L by the helper T cell and is directed by cytokines Antigen-binding B cells are trapped in the T-cell zone of secondary lymphoid tissues and are activated by encounter with armed helper T cells The second phase of the primary B-cell immune response occurs when activated B cells migrate to follicles and proliferate to form germinal centers Germinal center B cells undergo V-region somatic hypermutation and cells with mutations that improve affinity for antigen are selected


Charles A. Janeway Jr (1943–2003)

Charles A. Janeway, Jr. Diane Martindale dmartindale writescience. He was 60 years old. After earning his medical degree from Harvard Medical School in , Janeway joined a long family line of prominent physicians, which included his great great-grandfather, Edward Janeway, who was a New York City health commissioner. In , he was promoted to a professor of pathology, and in , he became one of the founding members of the newly created section of immunobiology at Yale University School of Medicine. By this, Janeway meant the requirement for adjuvants, notably those containing bacteria or bacterial extracts, in order to generate immune responses.

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